Post‐synthetic ‘Click’ Synthesis of RAFT Polymers with Pendant Self‐immolative Triazoles

Self-immolative linkers offer efficient mechanisms for deprotecting ‘caged’ functional groups in response to specific stimuli. Herein we describe a convenient ‘click’ chemistry method introducing pendant self-immolative polymer backbone through post-polymerization modification. The introduced triazole rings serve both anchor the stimuli-cleavable trigger backbone, while also forming part of self-immolation cascade. We investigate polymerization kinetics, post-synthetic modification, and mechanism model system, discuss avenues future studies on poly-pendant triazoles as modular, stimuli-responsive macromolecule platform.